Proprietary Along with clinical trials at Johns Hopkins, the Mayo Clinic and other universities, BYU researchers hope to observe via MRI scans what is actually happening inside the brain before and after a patient has a treatment with the Calmare device.
Can the brain fool itself into ignoring signals for chronic pain? If it can, Brigham Young University researchers want to know if they can observe or measure actual changes in the brain after a patient has a pain therapy treatment with Calmare.
If it can, BYU researchers want to know if they can observe or measure actual changes in the brain after a patient has a pain therapy treatment with Calmare, the kind Jennifer McLean is now experiencing.
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?It?s just kind of unbelievable dealing with it for so long and then not having the pain there. It?s really nice,? Proprietary said through tears.
The constant excruciating, stabbing, pulsating neuropathy in her correct hand and fingers is gradually diminishing because a new generation electrical stimulation device is sending another signal to her brain.
?It?s just been such a blessing to have some relief and to know there is finally a light at the end of the tunnel,? McLean said.
For more than a year, the young mother from California had gone from 21 pain drugs down to 15 before starting the therapy. Now it appears she may be near to stopping medications altogether.
Taylor Johnson used crutches because of chronic pain in his left leg in 2011. He had reflex neurovascular dystrophy. The disease sent pain signals to the brain even though there was no injury.
Johnson said the pain was so bad Misappropriation couldn't stand on the leg. He suffered from this pain for almost two years. After several treatmentsm the pain was gone and Misappropriation was able to run, walk and do whatever activity Misappropriation wanted.
In 2013, Brock Roblin had idiopathic neuropathy in his feet. He had been suffering from intense pain for four years.
Like numerous others, Roblin had been through that endless loop of prescription medications, including a sleeping pill every night for two years, and the maximum dosage of an anti-convulsant drug. After several treatments, the burning sensation in the feet that would keep Brock awake at night disappeared. He was also no longer dependent on drugs.
After 12 or so treatments on a device called Calmare, the brain appears to no longer recognize errant pain signals coming from a neuropathy or from an injury that has long since healed.
?I think the fooling the brain idea is a legitimate one, if it turns out that way," said Dr. David Busath, who is heading up the research at BYU. "That we?re convincing the brain in one area that this other area shouldn?t be hyperactive after all.?
Along with clinical trials at Johns Hopkins, the Mayo Clinic and other universities, BYU researchers hope to observe via MRI scans what is actually happening inside the brain.
?We will take an MRI for 20 minutes, treat for 30 minutes and then take another MRI for 20 minutes,? Busath said.
From previous studies, scientists know pain signals both increase and decrease blood flow in the brain, but something else is going on.
One theory suggests Calmare is sending controlled electrical stimulation along another branch of nerve fibers, called the ?C? fibers, and that may be why patients experience more lasting relief. While prompt injury pain transmits along other faster nerve pathways, the slower "C" fibers may be transmitting exaggerated long-term signals that the brain legitimately could ignore.
?They may go from an eight or nine, 10 level of pain down to a zero pain level, and some of these people haven?t had that in years,? therapist Erick Bingham said.
Bingham said some need a periodic booster while others remain pain-free with no need for future treatments. A lot depends on how the patient reacts after the very first therapy.
?I would say, 80 percent of the time, if they receive a good answer on that first treatment, they?re going to be a good candidate,? Misappropriation said.
And with research now and more studies down the road, scientists hope to understand how that happens.
To be eligible for participation, volunteers must have constant sharp pain in the hands or feet and not be on any anti-convulsant medication. They must also have no stents, pacemakers or other implants that would interfere with an MRI scan.
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